Rabeprazole Protection of Aspirin Induced Gastric Damage.

Thirty (30) normal subjects will be recruited. Inclusion criteria: * A normal subject must be between 18 and 60 years of age with no history of gastrointestinal disease, gastroduodenal surgery, upper gastrointestinal symptoms or cardiopulmonary disease of any kind. Exclusion Criteria: * Normal subjects should have not ingested a salicylate, nonsteroidal antiinflammatory drug, histamine-2 receptor antagonist, proton pump inhibitor, misoprostol or carafate within one month of entering this study. * He/she should not have participated in an investigational study within 3 months of this protocol. * Pregnant women and women not using an accepted method of birth control will be excluded. * Patients will be excluded who are allergic to aspirin and NSAIDs, who have an intolerance to aspirin and NSAIDs, who have a history of asthma and/or nasal polyps. * Patients will be excluded if they have a history of gastric ulcers, duodenal ulcers, gastrointestinal bleeding, or bleeding disorder, clotting disorder. * Patients will be excluded who actively abuse alcohol, as defined by greater than three twelve ounce beers or greater than three drinks containing hard liquor per day. * Patients with a history of intracranial bleeding and/or brain trauma will be excluded from this research.