Treatment of Cocaine Dependence: Comparison of Three Doses of Dextro-Amphetamine Sulfate and Placebo

Inclusion Criteria: * DSM-IV diagnosis of cocaine dependence, as determined by the Structured Clinical Interview for DSM-IV * Agreement to use an adequate method of contraception for the duration of the study * Electrocardiogram confirmation by a cardiologist * Cocaine-positive urine test prior to study entry Exclusion Criteria: * High blood pressure * Significant heart disease * Clinically significant cardiovascular abnormality * Angina * Kidney, liver, or gastrointestinal disorder * Current Axis I disorder not related to drug use * Current dependence on any drug other than nicotine * Attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) * On probation or parole for reasons other than those related to drug abuse charges * Pregnant or breastfeeding * Sought treatment for drug dependence within 3 months prior to study entry * Currently taking prescribed medications