Medications for Stopping Cocaine Dependence and Preventing Relapse

Inclusion Criteria: * Meets DSM-IV criteria for current cocaine dependence Exclusion Criteria: * Meet diagnostic criteria for other serious psychiatric symptoms and/or disorders that would interfere with participation in the treatment study (e.g., psychosis; mania; suicidal/ homicidal ideation) including other forms of drug dependence, nicotine and cannabis excepted. * Medical conditions contraindicating naltrexone therapy (e.g., past history of opioid use in the 30 days prior to study entry or significant hepatocellular injury) * Medical conditions contraindicating modafinil therapy (e.g., hypertension, seizures, arrhythmia, or coronary artery disease) * Medical conditions contraindicating levodopa/carbidopa therapy (e.g., severe pulmonary/cardiovascular disease, narrow angle glaucoma, melanoma, history of peptic ulcer, or renal function impairment) * Requires certain medications * Current or recent treatment for substance use or other psychiatric condition * On parole or probation that requires reports of drug use to officers of the court * Pending incarceration * Pregnant or breastfeeding * Unable to read, write, or speak English * Plans to leave the study area within 3 months of study entry