Metabolic Effects of Antipsychotics in Children

Inclusion Criteria: * Aged 6-18 years * Generally healthy and a score of ≥ 18 on the Aberrant Behavior Checklist in the context of one or more Axis I Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) childhood psychiatric disorders, including conduct disorder, oppositional defiant disorder, disruptive behavior disorder, autism, pervasive developmental disorder, attention deficit disorder, schizophrenia and bipolar affective disorders * Children's Global Assessment Scale (CGAS) score ≤ 60 * Not previously treated with an antipsychotic; individual subjects with remote, brief prior antipsychotic exposure may be considered for enrollment by the PI on a case by case basis * Patient assent and informed consent obtained from the parent or guardian * No clinically significant (based on PI determination) changes in permitted medications (e.g., stimulants and selective serotonin reuptake inhibitors \[SSRIs\]) for approximately 1 month prior to Baseline evaluations Exclusion Criteria: * Active suicidality or primary dx of major depressive disorder * Any lifetime use of antipsychotics or non-serotonin selective reuptake inhibitor (non-SSRI) anti-depressants * The presence of any serious medical disorder, based on PI determination, that may confound the assessment of relevant biologic measures or diagnoses, including: * significant organ system dysfunction; * endocrine disease, including type 1 or type 2 diabetes mellitus; * coagulopathy; * anemia;…