Primary Systemic Therapy in Operable/Locally Advanced Breast Cancer

Inclusion Criteria: * The diagnosis of breast cancer established by biopsy. * Normal kidney function * Normal LVEF evaluated by MUGA Scan * \>18 years of age * Good performance status defined by ECOG scale of 0 or 1 * Consent * Women of childbearing potential must have a negative pregnancy test. * Use of effective means of contraception in subjects of child-bearing potential while on treatment and for at least 3 months thereafter. * Peripheral Neuropathy: must be \< grade 1 * Hematologic (minimal values) * Absolute neutrophil count \>1,500/mm3 * Hemoglobin \>8.0 g/dl * Platelet count \>100,000/mm3 * Hepatic * Total bilirubin \<ULN * AST, ALT, Alkaline Phosphatase must be within range Exclusion Criteria: * Patients with locally advanced breast cancer with skin ulcerations * Stage IV breast cancer * Inflammatory breast cancer * Allergy to any component of the treatment regimen * Women who are breast feeding * Pregnancy or refusal to use effective contraception * Inability to comply with study and/or follow-up procedures. * Current, recent, or planned participation in a experimental drug study * Blood pressure of \>150/100 mmHg. Essential hypertension well controlled with anti hypertensives is not an exclusion criterion. * unstable angina * New York Heart Association Grade II or greater congestive heart failure * history of myocardial infarction within 6 months * history of stroke within 6 months * Clinical significant peripheral vascular disease * Evidence of bleeding diathe…