HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001)

Inclusion Criteria: * Age \>18. * Be able to provide written consent to perform in the trial. * HIV antibody positive at time of entry to the study. Specific to HIV Infection and Metabolic Abnormalities Protocol 1 (HAMA) part A only: * Be naive to antiretroviral medication. Specific to HAMA part B only: * Have had a minimum total exposure to antiretroviral medications (to include drugs from more than one drug class) of 48 weeks at time of recruitment. * Have had a minimum of 48 weeks interval since completion of HAMA part A. Exclusion Criteria: * Any history of, or ongoing, mental or physical condition (including suspected or known diagnosis of ischaemic heart disease), which, in the opinion of the investigator, would impede the subject's ability to participate in the trial. * Prior use of growth hormone or glucocorticoid or anabolic steroid products within the previous six months. * Prior use of supraphysiological doses of testosterone or oestrogen replacement therapy within the previous year. * Alcohol or substance abuse which in the opinion of the investigator would affect the patients ability to participate in the trial. * Prior use of any retinoid-containing compound within the previous six months. * Abnormal coagulation. * Previous allergic reaction or known allergy to local anaesthetic. * Previous or concomitant use of medications, which, in the opinion of the investigator, would affect the subject's ability to participate in all activities involved in the trial…