Recombinant Human Prolactin for Lactation Induction

Inclusion Criteria: * Healthy women, aged 18-45 years * Prolactin deficiency due to congenital deficiency, surgery or radiation, or Sheehan's syndrome during the current or previous pregnancies, for women who desire to breastfeed their infants. * Postpartum at the time of study participation * Milk must fail to come in by 2-4 days after delivery. * Prolactin levels will be less than the lower limit of normal for the assay performed. If a subject is postpartum, prolactin levels will be less than the normal range for postpartum women (\<= 138.0 ± 11.9 ng/mL). * Free T4 index must be normal either on or off thyroid hormone replacement. * Fasting am cortisol or 1 hour Cortrosyn 0.25 mg stimulated cortisol must be normal (\>18 mg/dL). If it is not normal, subjects must be on glucocorticoid replacement and have no symptoms of adrenal insufficiency. * History of normal spontaneous puberty or Tanner stage V breast development after previous estrogen replacement therapy. Exclusion Criteria: * Current use of medications known to increase or decrease prolactin * Anatomical breast abnormalities * Previous mammoplasty * Breast augmentation * Current use of hormonal contraception * Allergies to mannitol * Medications contraindicated for breastfeeding mothers