Stem Cell Transplant for Hemoglobinopathy

Inclusion Criteria: * Patients with Sickle Cell Disease/Thalassemia (SCD/THAL) 0-50 years of age with an acceptable stem cell donor and disease characteristic defined by the following: * Stroke, central nervous system (CNS) hemorrhage or a neurologic event lasting longer than 24 hours, or abnormal cerebral magnetic resonance imaging (MRI) or cerebral arteriogram or MRI angiographic study and impaired neuropsychological testing * Acute chest syndrome with a history of recurrent hospitalizations or exchange transfusions * Recurrent vaso-occlusive pain 3 or more episodes per year for 3 years or more years or recurrent priapism, * Impaired neuropsychological function and abnormal cerebral MRI scan * Stage I or II sickle lung disease, * Sickle nephropathy (moderate or severe proteinuria or a glomerular filtration rate \[GFR\] 30-50% of the predicted normal value) * Bilateral proliferative retinopathy and major visual impairment in at least one eye * Osteonecrosis of multiple joints with documented destructive changes * Requirement for chronic transfusions but with red blood cell (RBC) alloimmunization \>2 antibodies during long term transfusion therapy * Patients with transfusion dependent alpha- or beta-thalassemia 0-35 years of age with an acceptable stem cell donor as defined in the criteria in section above. * Patients with other non-malignant hematologic disorders that are transfusion-dependent or involve other potentially life-threatening cytopenias (incl…