Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet's Disease (INCYTOB)

Inclusion Criteria: * Behçet's disease fulfilling the International Study Group Criteria with active pan- or posterior uveitis (according to the posterior uveitis scoring system) or retinal vasculitis and active disease according to the Behcet's Disease activity scoring system. Exclusion Criteria: * Previous treatment with interferon-α or cyclosporin A * Pregnancy, breast feeding women, malignancy * Renal impairment (creatinine \> 1.5 mg/dl) * Uncontrolled hypertension or diabetes * Depression or other psychic disorders(also history of depression) * History of acute or chronic inflammatory joint or autoimmune disease * Organ or bone marrow transplant recipient, cardiac failure \> NYHAIII * Acute liver disease with SGPT 2x above normal * White blood cell count \< 3500/mm3 * Platelet count \< 100000/mm3 * Hgb \< 8.5g/dl * Body weight \<45 kg * Alcohol abuse or drug abuse * Mental impairment * Uncooperative attitude