Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic⦠(NCT00161187) | Clinical Trial Compass
CompletedPhase 1
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
United States37 participantsStarted 2001-05
Plain-language summary
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
PURPOSE: This pilot study is looking at the side effects and how well irradiated donor lymphocyte infusion works in treating patients with relapsed or refractory hematologic cancer or solid tumor.
Who can participate
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed diagnosis of 1 of the following:
* Hematologic cancer, including any of the following:
* Chronic lymphocytic leukemia or small lymphocytic lymphoma meeting any of the following criteria:
* Relapsed within 1 year after prior fludarabine phosphate-containing regimens OR not a candidate to receive such therapy due to comorbidities or allergies
* Received prior anti-CD52 monoclonal antibody therapy OR ineligible to receive such therapy (for patients without symptomatic lymphadenopathy)
* Has documentation of disease-associated symptoms, rapid progression of disease, or other indications for treatment
* B- or T-cell prolymphocytic leukemia meeting any of the following criteria:
* Relapsed within 1 year after prior fludarabine phosphate- or alkylating agent-containing regimens OR not a candidate to receive such therapy due to comorbidities or allergies
* Relapsed within 1 year after prior anti-CD20 monoclonal antibody therapy OR ineligible to receive such therapy (for patients with CD20-positive disease)
* Received prior anti-CD52 monoclonal antibody therapy OR ineligible to receive such therapy (for patients without symptomatic lymphadenopathy)
* Lymphoplasmacytic lymphoma, marginal zone lymphoma, mucosa-associated lymphoid tissue lymphoma, or follicular lymphoma meeting any of the following criteria:
* Relapsed within 1 year after prior fludarabine phosphate- or alkylā¦
What they're measuring
1
Toxicity
Timeframe: 10 years
Trial details
NCT IDNCT00161187
SponsorUniversity of Medicine and Dentistry of New Jersey