MEND-CABG (MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery)

Inclusion Criteria: Patients must be scheduled to undergo CABG surgery (during routine scheduling times) planned to use cardiopulmonary bypass Patients must be considered at high risk for subsequent neurological or myocardial complications defined as meeting 2 or more of the following: * Age \>65 * Current smoker * History of diabetes mellitus requiring treatment other than diet * Evidence of left ventricular dysfunction or congestive heart failure assessed by: ejection fraction (EF) \<45%, left ventricular end diastolic pressure (LVEDP) or pulmonary wedge pressure greater than or equal to 20 mm Hg, pulmonary edema by chest X-ray, cardiothoracic ratio \>50% on chest X-ray * History of a previous non-disabling stroke, transient ischemic attack, or carotid endarterectomy * Urgent CABG intervention defined as the need to stay in the hospital (although patient may be operated on within a normal scheduling routine * History of a myocardial infarction that occurred more than 48 hours but less than 6 weeks prior to CABG surgery * Prior peripheral artery surgery or angioplasty * Moderate renal dysfunction defined by creatinine ≥ 133 micromol/L (1.5 mg/dL), but \< 250 micromol/L (2.8 mg/dL) * Presence of at least one asymptomatic carotid artery stenosis (≥50%) either in one or two carotid arteries Exclusion Criteria: * Planned associated valve surgery or concurrent carotid endarterectomy * Planned aortic dissection repair or aortic root reconstruction * Screening visit occurring …