Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases

Inclusion Criteria: * Patients ≥ 15 years of age * Life threatening disease documented by conventional criteria to be resistant to standard, approved therapy. * Experimental documentation of functional significance of either Abl, Kit (CD117), or PDGF-R in the relevant target tissue (preferably on a sample taken within 6 weeks of study entry). * ECOG Performance status of 0, 1, or 2. * Adequate end organ function defined as: total bilirubin \< 1.5 x ULN, SGOT and SGPT \< 2.5 x UNL (or \< 5 x ULN for patients with hepatic disease), creatinine \< 1.5 x ULN, ANC \> 1.5 x 109/L, platelets \> 100 x 109/L. * Negative serum or urine pregnancy test for women of child bearing potential (WOCBP) within 7 days of study initiation. Post menopausal women must have experienced amenorrhea for at least 12 months. Male and female patients must use effective birth control methods throughout the study and for up to 3 months after study discontinuation. * Life expectancy of more than 3 months. * Written, voluntary, informed consent for retrieval, evaluation and investigational use of tissue samples. Exclusion Criteria: * Patients who have received any other investigational agent within 28 days of study initiation. * Patients with another primary malignancy except if other primary malignancy is neither currently clinically significant nor requiring active intervention. * Patients with Grade III/IV cardiac problems defined by the New York Heart Association Criteria (e.g. congestive heart failure,…