Efficacy and Safety of the ACAT Inhibitor CS-505 (Pactimibe) for Reducing the Progression of Carotid Artery Disease. This Study is Also Known as CAPTIVATE.

Inclusion Criteria: * Confirmed diagnosis of heterozygous familial hypercholesterolemia * Ambulatory male (40 to 75 years, inclusive) or female (45 to 75 years, inclusive) subjects * Calculated LDL-C level greater than or equal to 100 mg/dL (or 2.5 mmol/L) and triglycerides less than 500 mg/dL (5.65 mmol/L) while on usual and stable lipid-lowering therapy Exclusion Criteria: * Breast feeding or lactating women * Previous organ transplantation * High-grade stenosis (\>75%) or the occlusion of any segment of either carotid artery * History of carotid endarterectomy, or insertion of carotid artery stent or are scheduled to have either of these procedures