Baseline Sexual Function, Cognitive Function, Body Composition and Muscle Parameters and Pharmacokinetics of Transdermal Testosterone Gel in Women With Hypopituitarism

Inclusion Criteria: * Women age 18-55 * Hypopituitarism with documented central adrenal and gonadal deficiencies. Serum testosterone level of \< 20 ng/dl or free testosterone \<1.5 pg/ml on conjugated equine estrogen replacement * No other significant medical condition * Weight between 80 and 150% of ideal body weight * Able to provide informed consent * All races and ethnicities * All patients regardless of marital status and relationship status Exclusion Criteria: * Physical disabilities that would prevent them from participating in the study * Current use of testosterone or other androgenic steroids. Patients who are taking testosterone, DHEA or other androgen precursors will discontinue these medications/supplements three months prior to the study. * Significant cardiopulmonary disease, renal disease (creatinine \> 1.5 mg/dL), diabetes mellitus, uncontrolled hypertension, malignancy (other than basal cell skin carcinoma) or major psychiatric disease. Patients with depression or anxiety on a stable dose of medication will be allowed to enroll. * Current abuse of illicit drugs or heavy ethanol use * History of breast or uterine cancer * Those with significant liver function abnormalities defined as SGOT, SGPT or alkaline phosphatase value of greater than one and one-half times the upper limit of normal in our Clinical Pathology Laboratory or serum bilirubin levels of greater than 2 mg/dl will be excluded. * Those with history of hyperandrogenic disorders such as hirsutis…