The Study of Atherosclerosis With Ramipril and Rosiglitazone

Inclusion Criteria: * impaired glucose tolerance (FPG \< 7 mmol/L or 126 mg/dL \& 2hr PG between 7.8-11.0 mmol/l \[140-199 mg/dl\] after a 75 g OGTT * impaired glucose tolerance (FPG≥ 6.1 mmol/l \[110 mg/dl\]) and no diabetes (i.e. a FPG \< 7.0 mmol/l \[126 mg/dl\]) * a technically adequate baseline carotid ultrasound examination Exclusion Criteria: * current use of an ACE-inhibitor (ACE-I) or thiazolidinedione (TZD) * known hypersensitivity to ACE-I * prior use of anti-diabetic medications 9with the exception of during pregnancy) * use of systemic glucocorticoids or niacin * congestive heart failure or EF \< 40% * existing cardiovascular disease (previous MI, stroke, angina, uncontrolled hypertension) * diabetes * renal or hepatic disease * major illness * use of another experimental drug * pregnant or unwilling to use reliable contraception * major psychiatric disorder * diseases that affect glucose tolerance * unwillingness to be randomized or sign informed consent * known uncontrolled substance abuse * inability to communicate with research staff