Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis (NCT00138801) | Clinical Trial Compass
CompletedPhase 3
Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis
Norway120 participantsStarted 2004-03
Plain-language summary
The aim of this study is to compare parenteral ceftriaxone and oral doxycycline in the treatment of neuroborreliosis in a randomized controlled trial.
Who can participate
Age range18 Years – 100 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Neurological symptoms and/or findings consistent with neuroborreliosis and at least one of the following fulfilled:
* Intrathecal production of borrelia antibodies;
* White cell count in cerebrospinal fluid (CSF) \> 5/mm3;
* Significant rise in borrelia antibodies in two serum samples collected from a patient with at least 3 weeks interval;
* Verified acrodermatitis chronica atrophicans.
Exclusion Criteria:
* Allergy to the contents in the medication, or earlier type I reaction to penicillin.
* Treatment with cephalosporins, penicillin or tetracyclins during the last 14 days
* Pregnancy or breastfeeding
* Age \< 18 years