Suberoylanilide Hydroxamic Acid in Treating Patients With Metastatic and/or Locally Advanced or L… (NCT00134043) | Clinical Trial Compass
CompletedPhase 2
Suberoylanilide Hydroxamic Acid in Treating Patients With Metastatic and/or Locally Advanced or Locally Recurrent Thyroid Cancer
United States19 participantsStarted 2005-12
Plain-language summary
This phase II trial is studying how well suberoylanilide hydroxamic acid works in treating patients with metastatic and/or locally advanced or locally recurrent thyroid cancer. Drugs used in chemotherapy, such as suberoylanilide hydroxamic acid, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Suberoylanilide hydroxamic acid may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Histologically confirmed thyroid cancer
* One of the following subtypes:
* Papillary thyroid cancer
* Follicular thyroid cancer
* Hürthle cell thyroid cancer
* Insular thyroid cancer
* Medullary thyroid cancer
* Mixed histology thyroid cancer
* Poorly differentiated thyroid cancer
* Tall-cell thyroid cancer
* Metastatic and/or locally advanced or locally recurrent disease
* Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mm by conventional techniques OR ≥ 10 mm by spiral CT scan
* Lesions in a previously irradiated area allowed provided there has been subsequent disease progression of the irradiated lesions
* The following are not considered measurable disease:
* Bone lesions
* Leptomeningeal disease
* Ascites
* Pleural or pericardial effusion
* Lymphangitis cutis/pulmonis
* Abdominal masses not confirmed and followed by imaging techniques
* Cystic lesions
* Not a candidate for radioactive iodine I\^131 therapy
* Performance status - ECOG 0-1
* At least 6 months
* WBC ≥ 3,000/mm\^3
* Absolute neutrophil count ≥ 1,500/mm\^3
* Platelet count ≥ 100,000/mm\^3
* Bilirubin ≤ 1.5 mg/dL
* AST and ALT ≤ 2.5 times upper limit of normal
* Creatinine ≤ 1.5 mg/dL
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* No history of allergic reaction attributed to compounds of similar chemical or biologic composition to …
What they're measuring
1
Objective Response Rate (PR + CR) Using RECIST/WHO Response Criteria