RCT ALB for SA Cysticercosis (NCT00133458) | Clinical Trial Compass
WithdrawnPhase 3
RCT ALB for SA Cysticercosis
Brazil, Colombia, Ecuador0
Plain-language summary
This study will enroll 120 individuals diagnosed with subarachnoid cysticercosis, a disease caused by the invasion of the basal part of your brain by a parasite named Taenia solium. Subarachnoid cysticercosis is usually treated with albendazole for one month to kill the parasite. This study will determine if two months of albendazole (ABZ) therapy is better than one-month. The study will last 3 years.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion Criteria:
* Male or female individuals between 18-65 year of age with a diagnosis of basal subarachnoid cysticercosis, based on MRI and confirmed by serological test.
* Willingness to accomplish the two weeks minimal hospitalization required.
* Female of child-bearing potential willing to use an adequate method of contraception including implants, injectables, combined oral contraceptives, effective intrauterine devices, sexual abstinence, or vasectomized partner while participating in the study.
* Patients with normal laboratory values for hemoglobin, platelet counts, total white blood cells, glucose, creatinine, bilirubin, ALT, AST, and electrolytes.
* Negative fecal exam for Taenia eggs.
Exclusion Criteria:
* Previous therapy with albendazole (does not include patients who received single-dose 400 mg ABZ for intestinal parasites), or praziquantel.
* Pulmonary tuberculosis evidenced by a positive chest X-ray and positive sputum smears.
* Pre-existing diagnosis of diabetes
* Systemic disease other than NCC that may affect therapy or short-term prognosis, including but not limited to chronic renal failure, hepatic insufficiency, cardiac failure, and steroid-dependent immune diseases. Identification of systemic diseases will be left to the discretion of each Site PI.
* Patients in unstable condition or with severe intracranial hypertension (ICH). Definition of severe ICH for this study would be the presence of headaches, nausea, and vomiting and papilledema at fun…
Trial details
NCT IDNCT00133458
SponsorNational Institute of Allergy and Infectious Diseases (NIAID)