Drug-eluting-stents for Unprotected Left Main Stem Disease (ISAR-LEFT-MAIN)

Inclusion Criteria: * Patients older than age 18 with ischemic symptoms or evidence of myocardial ischemia in the presence of ≥50% stenosis located in unprotected LMCA who are unable to undergo coronary artery bypass graft (CABG) * Pretreatment with a loading dose of 300-600 mg clopidogrel * Informed, written consent Exclusion Criteria: * Cardiogenic shock; * ST-segment elevation acute myocardial infarction within 48 h from symptom onset; * In-stent restenosis; * Malignancies or other comorbid conditions with life expectancy less than one year; * Prior coronary artery bypass surgery with revascularization of left anterior descending (LAD) and/or left circumflex (LCx) coronary artery * Planned staged percutaneous coronary intervention (PCI) procedure within 30 days from index procedure or prior PCI within the last 30 days * Left main size \>4.5mm * An elective surgical procedure is planned during the first six months post enrolment; * Known allergy to the study medications * Pregnancy * Patient's inability to fully cooperate with the study protocol