Is Myopathy Part of Statin Therapy (IMPOSTER-16)

Inclusion Criteria: * Primary doctor's permission * Patient understands nature of study and has signed consent * Patient is \>21 years of age * Patient willing to stop statin for up to 12 weeks and remain off CoQ10 for study duration * Patient able to perform the strength and functional tests required * Patient complains of muscle weakness or aching which he/she or his/her physician feels may be attributable to statin therapy * CK \< 350 IU * Thyroid stimulating hormone (TSH) must be normal * Fasting respiratory exchange ratio (RER) \> 0.80 off statin for at least 4 weeks Exclusion Criteria: * Severe underlying illness including: Cr \> 3.0, liver failure, unstable angina, symptomatic valvular heart disease, congestive heart failure, or prior cerebrovascular accident (CVA) preventing exercise testing. * History of muscle damage (CK \> 350 IU) on statins * Underlying musculoskeletal disorder preventing muscle testing * History of severe depression * Taking doses of other medicines with statin sufficient to cause myopathy including: cyclosporine, erythromycin or other macrolide antibiotics; fluconazole; niacin; fibrates; or \> 16 oz. of grapefruit juice daily. * Diabetes requiring other than diet therapy * Use of thiazolidinediones (TZD's), protease inhibitors or other drugs known to influence RER or fatty acid oxidation. * Abnormal thyroid status * Inability to maintain constant exercise, dietary, and drug regimen during the 16 weeks required by the study protocol.