Intravitreal Microplasmin in Patients Undergoing Surgical Vitrectomy

Inclusion Criteria: * Patients with vitreomacular traction maculopathy for whom vitrectomy is indicated, according to the principal investigator, including: * Macular edema associated with vitreomacular traction (DME, VMTS); * Stage II-III macular hole of \< 6 months duration since symptom onset; * Demonstration of vitreomacular adhesion (based on preoperative optic coherence tomography \[OCT\]) in the study eye; * OCT - presence of posterior hyaloid membrane inserting on to the macula, but with some area of clear separation visible between the retina and the posterior hyaloid. Exclusion Criteria: * Evidence of fibrocellular proliferation characterized by whitish epimacular tissue (surface wrinkling is not an exclusion criterion). * Patients with vitreous hemorrhage which precludes either of the following: visualization of the posterior pole by visual inspection OR adequate assessment of the macula by either OCT and/or fluorescein angiogram in the study eye. * Patients with rhegmatogenous retinal detachment, proliferative vitreoretinopathy (PVR), or retinal degenerative changes in the study eye. * Patients with high myopia or aphakia in the study eye * Patients with history of rhegmatogenous retinal detachment in the fellow eye or family history of retinal detachment * Patients who are considered likely to require intraocular surgery in the study eye for any reason other than vitreomacular traction maculopathy/macular edema in the coming three months. * Patients w…