Study of REN-1654 in Patients With Sciatica Pain

Inclusion Criteria: * Males or females, ages 18 to 55, able and willing to provide written informed consent to participate in the study. * Able to read, understand and follow the study instructions, including completion of pain intensity rating scales. * Leg pain radiating to or below the knee in a dermatomal pattern, diagnosed as being due to sciatica or lumbar or lumbosacral radiculopathy, the onset of which occurred 2 to 12 weeks prior to initiation of study treatment. * Leg pain severity on a screening Categorical Pain Intensity Rating (for the prior 24 hour period) of at least 4, using an 11-point categorical pain intensity scale with 0 = no pain and 10 = worst pain imaginable. * Leg pain on a screening Categorical Pain Intensity Rating rated as more severe than back pain. * Positive straight leg raising (SLR) test as defined in Appendix B of this protocol. * Subjects who are compliant in maintaining a Pain Diary between screening and baseline visits, and who record a 24-hour average Categorical Pain Intensity Rating score of at least 4 or greater on at least 3 days during the week prior to baseline visit. * Subject who can maintain stable pharmacologic treatments for sciatica symptoms taken prior to dosing including analgesics, anti-inflammatory medications (e.g. NSAIDS), antidepressants, anticonvulsants, anxiolytics, or muscle relaxants. Subjects must be on stable doses of such medications for 2 weeks prior to the baseline visit, and maintained on the same doses throu…