Temsirolimus in Treating Patients With Metastatic Neuroendocrine Carcinoma

Inclusion Criteria: * Patients must have histologically or cytologically confirmed neuroendocrine tumours either of carcinoid histology or a carcinoma of pancreatic islet cell origin; small cell variant, endocrine organ carcinomas, and adrenal gland malignancies (including paragangliomas) are excluded from this study * Patients must have progressive metastatic disease defined by one of the following occurring within 6 months of study entry: * At least a 25% increase in radiologically or clinically measurable disease * Appearance of any new lesion or * Deterioration in clinical status * Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as \>= 20 mm with conventional techniques or as \>= 10 mm with spiral CT scan * Previous local therapy (e.g. chemoembolization or bland embolization) allowed if completed \> 6 weeks prior to study entry; for patients who received local therapy prior to study entry, there must be either progression of measurable disease documented within the treatment field, or must have measurable disease outside the treatment field prior to study entry * Previous chemotherapy, investigational agents or radioactive therapies (e.g. radioactive octreotide) allowed if completed \> 4 weeks prior to study entry (\> 6 weeks if last regimen contained BCNU or mitomycin C); for patients who received systemic therapy prior to study entry, there must be d…