Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer (NCT00093678) | Clinical Trial Compass
WithdrawnNot Applicable
Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer
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Plain-language summary
RATIONALE: Celecoxib may help relieve moderate or severe pain associated with cancer. It may also decrease weight loss and improve muscle strength in cancer patients.
PURPOSE: This randomized clinical trial is studying celecoxib to see how well it works in managing pain, weight loss, and weakness in patients with advanced cancer.
Who can participate
Age range18 Years – 120 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically or cytologically confirmed malignant tumor of 1 of the following types:
* Carcinoma
* Sarcoma
* Melanoma
* Lymphoma
* Metastatic or unresectable disease
* Clear evidence of residual disease after most recent prior treatment
* Measurable disease not required
* Patient has elected to receive supportive care only rather than active cancer treatment (e.g., palliative chemotherapy)
* Brain metastases allowed provided the following criteria are met:
* Completed treatment for CNS disease (e.g., whole brain radiotherapy, surgery, or stereotactic surgery)
* Clinically stable disease for at least 4 weeks after treatment completion
* No requirement for corticosteroids
PATIENT CHARACTERISTICS:
Age
* 18 and over
Performance status
* ECOG 0-3
Life expectancy
* Not specified
Hematopoietic
* Not specified
Hepatic
* Bilirubin ≤ 2 times upper limit of normal (ULN)
* ALT and AST ≤ 5 times ULN
Renal
* Creatinine ≤ 1.6 mg/dL
Cardiovascular
* No myocardial infarction within the past 6 months
* No transient ischemic attack within the past 6 months
* No stroke within the past 6 months
* No angina pectoris requiring medical therapy
* No other active coronary artery disease or cerebrovascular disease
Other
* No active gastrointestinal (GI) ulcer disease
* No GI bleeding
* No history of allergic reaction, urticaria, or bronchospasm after taking NSAIDs, aspirin, or sulfonamide drugs
* Not pregnant or nursing
* Negative pregna…