Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Pre… (NCT00091182) | Clinical Trial Compass
CompletedPhase 2
Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment
United States180 participantsStarted 2004-10
Plain-language summary
This phase II trial is studying how well oxaliplatin works in treating young patients with recurrent solid tumors that have not responded to previous treatment. Drugs used in chemotherapy, such as oxaliplatin, work in different ways to stop tumor cells from dividing so they stop growing or die.
Who can participate
Age range21 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Histologically confirmed\* solid tumor, including any of the following:
* Ewing's sarcoma/peripheral primitive neuroectodermal tumor (PNET)
* Osteosarcoma
* Rhabdomyosarcoma
* Neuroblastoma
* High-grade astrocytoma
* Low-grade astrocytoma
* Glioblastoma multiforme
* Ependymoma
* Hepatoblastoma
* Germ cell tumors of any site
* Rare tumors of interest, including any of the following:
* Soft tissue sarcoma
* Hepatocellular carcinoma
* Childhood/adolescent colorectal carcinoma
* Childhood/adolescent renal cell carcinoma
* Childhood/adolescent adrenocortical carcinoma
* Childhood/adolescent nasopharyngeal carcinoma
* Recurrent disease OR refractory to conventional therapy
* Measurable disease by clinical exam, CT scan, MRI, or positron emission tomography
* Performance status - Karnofsky 50-100% (for patients over age 10)
* Performance status - Lansky 50-100% (for patients age 10 and under)
* At least 8 weeks
* Absolute neutrophil count ≥ 1,000/mm\^3\*
* Platelet count ≥ 75,000/mm\^3\* (transfusion independent)
* Hemoglobin ≥ 8.0 g/dL\* (RBC transfusions allowed)
* Granulocytopenia, anemia, and/or thrombocytopenia due to bone marrow metastases or extensive prior radiotherapy allowed provided the above hematological criteria are met
* Bilirubin ≤ 3 mg/dL
* Creatinine based on age as follows:
* ≤ .8 mg/dL (for patients age 5 and under)
* ≤ 1.0 mg/dL (for patients age 6 to 10)
* ≤ 1.2 mg/dL (for patients ag…