Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or N… (NCT00082823) | Clinical Trial Compass
CompletedPhase 1
Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma
United States25 participantsStarted 2004-01
Plain-language summary
RATIONALE: Intravenous VEGF Trap may stop the growth of solid tumors or non-Hodgkin's lymphoma by stopping blood flow to the cancer.
PURPOSE: This phase I trial is studying the side effects of VEGF Trap in treating patients with relapsed or refractory advanced solid tumors or non-Hodgkin's lymphoma.
Who can participate
Age range18 Years – 120 Years
SexALL
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DISEASE CHARACTERISTICS:
* Histologically confirmed non-Hodgkin's lymphoma OR primary or metastatic solid tumor located in at least one of the following sites:
* Liver
* Soft tissue
* Pelvis
* Other site that is suitable for delayed contrast-enhancing MRI
* Relapsed or refractory disease
* Failed all conventional therapeutic options AND not amenable to existing therapeutic options
* Must have completed the active phase (through study visit 9) of MSKCC-03137 (VGFT-ST-0202) without experiencing dose-limiting toxicity
* No prior or concurrent CNS metastases (brain or leptomeningeal)
* No new neurological symptoms during treatment on MSKCC-03137 (VGFT-ST-0202)
PATIENT CHARACTERISTICS:
Age
* 18 and over
Performance status
* Not specified
Life expectancy
* Not specified
Hematopoietic
* No severe or uncontrolled hematologic condition
Hepatic
* Not specified
Renal
* No severe or uncontrolled renal condition
Cardiovascular
* No severe or uncontrolled cardiovascular condition
Pulmonary
* No severe or uncontrolled pulmonary condition
Other
* No severe or uncontrolled gastrointestinal, immunologic, or musculoskeletal condition
* No other medical or psychiatric condition or adverse social circumstance that would preclude study participation
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective double-barrier contraception during and for 3 months after study treatment
PRIOR CONCURRENT THERAPY:
Biologic therapy
* No c…