Akathisia (Restless Legs Syndrome) in People With Schizophrenia and Mental Retardation

Inclusion Criteria for Experimental Series I * Chronic akathisia for at least 3 months prior to study entry * Neuroleptic medication for at least 6 months prior to study entry (anticonvulsant medication will be accepted and those on carbamazepine and ethosuximide will be monitored for the development of akathisia) * Mental retardation/developmental delay diagnosis based on American Association of Mental Deficiency definition or diagnosis of schizophrenia based on the DSM-IV criteria Inclusion Criteria for Control Group * Control groups will be matched to akathisia groups based on age and level of disability (IQ for mental retardation population, BPRS positive symptoms of schizophrenia for schizophrenic groups). Exclusion Criteria * Psychotropic drugs such as serotonin re-uptake inhibiting anti-depressants * Nonambulatory * Uncontrolled seizure disorders * Fragile X syndrome * Down Syndrome * Neurological disease that is known to have definitive symptoms of choreoathetosis, dystonia, Syndenham's chorea, etc.