Combination Chemotherapy in Treating Patients With Previously Untreated Advanced Hodgkin's Lymphoma (NCT00041210) | Clinical Trial Compass
UnknownPhase 3
Combination Chemotherapy in Treating Patients With Previously Untreated Advanced Hodgkin's Lymphoma
United Kingdom850 participantsStarted 2001-10
Plain-language summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating patients who have advanced Hodgkin's lymphoma.
PURPOSE: Randomized phase III trial to compare the effectiveness of two different combination chemotherapy regimens in treating patients who have advanced Hodgkin's lymphoma.
Who can participate
Age range18 Years – 60 Years
SexALL
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DISEASE CHARACTERISTICS:
* Histologically confirmed Hodgkin's lymphoma (any sub-type)
* Stage IB, IIB, IIIA, IIIB, or IV OR
* Stage IA or IIA with locally extensive disease (e.g., bulky mediastinal disease (e.g., greater than 0.33 of the maximum transthoracic diameter on routine chest X-ray or at least 2 extranodal sites of disease))
PATIENT CHARACTERISTICS:
Age:
* 18 to 60
Performance status:
* Not specified
Life expectancy:
* Not specified
Hematopoietic:
* Complete blood count normal unless directly due to Hodgkin's lymphoma
Hepatic:
* Hepatic function normal unless directly due to Hodgkin's lymphoma
Renal:
* Renal function normal unless directly due to Hodgkin's lymphoma
Cardiovascular:
* No pre-existing cardiac disease
Pulmonary:
* No pre-existing pulmonary disease
Other:
* Not pregnant
* Fertile patients must use effective contraception during and for six months after study
* HIV negative
* No other prior malignancy except basal cell or squamous cell skin cancer
PRIOR CONCURRENT THERAPY:
Biologic therapy:
* Not specified
Chemotherapy:
* Not specified
Endocrine therapy:
* Not specified
Radiotherapy:
* Not specified
Surgery:
* Not specified
Other:
* No prior therapy for Hodgkin's lymphoma
What they're measuring
1
Relapse-free survival
Trial details
NCT IDNCT00041210
SponsorMount Vernon Cancer Centre at Mount Vernon Hospital