Imatinib Mesylate in Treating Patients With Refractory or Relapsed Ovarian Epithelial, Fallopian … (NCT00039585) | Clinical Trial Compass
CompletedPhase 2
Imatinib Mesylate in Treating Patients With Refractory or Relapsed Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer, or Ovarian Low Malignant Potential Tumor
United StatesStarted 2002-05
Plain-language summary
RATIONALE: Imatinib mesylate may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth.
PURPOSE: Phase II trial to determine the effectiveness of imatinib mesylate in treating patients who have refractory or relapsed ovarian epithelial, fallopian tube, or primary peritoneal cancer, or ovarian low malignant potential tumor.
Who can participate
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed ovarian epithelial, fallopian tube, or primary peritoneal cancer OR
* Histologically confirmed ovarian low malignant potential tumor with invasive recurrence
* Relapsed after and/or refractory to platinum- and taxane-based chemotherapy
* Patients in first relapse after a disease-free interval of more than 1 year are eligible
* Measurable disease outside prior radiation field
* Availability of a sentinel lesion that is adequate for core biopsy through percutaneous biopsy or simple laparoscopic means
* Patients with clinical evidence of CNS involvement (abnormal clinical examination) must have a negative CT scan with contrast or MRI of the brain
* No large volume ascites or pleural effusion
PATIENT CHARACTERISTICS:
Age:
* Not specified
Performance status:
* ECOG 0-2
Life expectancy:
* Not specified
Hematopoietic:
* WBC at least 3,000/mm\^3
* Absolute neutrophil count greater than 1,500/mm\^3
* Hemoglobin at least 9.0 g/dL (independent of epoetin alfa or transfusion)
* Platelet count at least 100,000/mm\^3
Hepatic:
* Bilirubin no greater than 1.5 mg/dL
* Transaminases no greater than 2.5 times upper limit of normal
Renal:
* Creatinine no greater than 1.5 mg/dL
Cardiovascular:
* No myocardial infarction or unstable dysrhythmia within the past 6 months
* No congestive heart failure (CHF), including CHF that may be compensated with furosemide
Other:
* No other invasive malignancy within the past 5 years except no…
What they're measuring
1
Clinical response in patients with epithelial ovarian cancer as measured by CT scan of chest, abdomen, and pelvis every 8 weeks