Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metas… (NCT00039572) | Clinical Trial Compass
CompletedPhase 1/2
Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain
United StatesStarted 2002-05
Plain-language summary
RATIONALE: Radiation therapy such as boron neutron capture therapy may kill tumor cells without harming normal tissue.
PURPOSE: Phase I/II trial to study the effectiveness of boron neutron capture therapy in treating patients who have glioblastoma multiforme or melanoma metastatic to the brain.
Who can participate
Age range18 Years
SexALL
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DISEASE CHARACTERISTICS:
* Histologically confirmed glioblastoma multiforme OR
* Radiographically diagnosed brain metastases after a diagnosis of melanoma
* Contrast-enhanced tumor volume must not exceed 60 mL
PATIENT CHARACTERISTICS:
Age:
* 18 and over
Performance status:
* ECOG 0-2
Life expectancy:
* At least 6 months
Hematopoietic:
* Not specified
Hepatic:
* Not specified
Renal:
* Creatinine normal
Cardiovascular:
* No prior severe cardiac disease, including the following:
* Uncontrolled arrhythmias or conduction defects
* Unstable or newly diagnosed angina pectoris
* Recent coronary artery disease
* Congestive heart failure
Other:
* Not pregnant
* Negative pregnancy test
* Fertile patients must use effective contraception during and for at least 6 months after study
* No prior phenylketonuria
* No cognitive impairment that would preclude informed consent
PRIOR CONCURRENT THERAPY:
Biologic therapy:
* Not specified
Chemotherapy:
* No concurrent chemotherapy
Endocrine therapy:
* Not specified
Radiotherapy:
* No prior cranial irradiation
Surgery:
* Not specified