VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma (NCT00036946) | Clinical Trial Compass
CompletedPhase 1
VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma
United StatesStarted 2001-11
Plain-language summary
RATIONALE: VEGF Trap may stop the growth of solid tumors or non-Hodgkin's lymphoma by stopping blood flow to the cancer.
PURPOSE: Phase I trial to study the effectiveness of VEGF Trap in patients who have relapsed or refractory solid tumors or non-Hodgkin's lymphoma.
Who can participate
Age range25 Years – 120 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed incurable primary or metastatic solid tumor or non-Hodgkin's lymphoma
* Relapsed after or is refractory (e.g., unresectable) to at least 2 standard chemotherapy regimens and rituximab
* No standard curative surgery, chemotherapy, immunotherapy, other antitumor therapy, or radiotherapy options exist
* No known or suspected squamous cell carcinoma of the lung
* No prior or concurrent CNS (brain or leptomeningeal) metastases
* No prior or concurrent primary intracranial tumor by MRI or CT scan
PATIENT CHARACTERISTICS:
Age:
* 25 and over
Performance status:
* ECOG 0-2
Life expectancy:
* Not specified
Hematopoietic:
* WBC at least 3,500/mm\^3
* Absolute neutrophil count at least 1,500/mm\^3
* Platelet count at least 100,000/mm\^3
* Hemoglobin at least 9.0 g/dL
* No other severe or uncontrolled hematologic condition
Hepatic:
* Bilirubin no greater than 1.5 times upper limit of normal (ULN)
* AST and ALT no greater than 2 times ULN
* Alkaline phosphatase no greater than 2 times ULN
* PT, PTT, and INR normal
Renal:
* Creatinine no greater than ULN
* No 1+ or greater proteinuria
* No other severe or uncontrolled renal condition
Cardiovascular:
* Electrocardiogram normal
* LVEF normal by echocardiogram or MUGA scan within the past 12 months or since completion of prior anthracycline
* No severe or uncontrolled cardiovascular condition
* No New York Heart Association class III or IV heart disease
* No active corona…