Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma (NCT00031915) | Clinical Trial Compass
CompletedPhase 2
Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma
United StatesStarted 2002-06
Plain-language summary
RATIONALE: Imatinib mesylate may stop the growth of tumor cells by blocking the enzymes necessary for cancer cell growth.
PURPOSE: Phase II trial to study the effectiveness of imatinib mesylate in treating patients who have metastatic or unresectable locally advanced soft tissue sarcoma or bone sarcoma.
Who can participate
Age range10 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically or cytologically confirmed metastatic or unresectable locally advanced (stage IV or recurrent) soft tissue or bone sarcoma
* Eligible subtypes:
* Ewing's family (e.g., primitive neuroectodermal tumor)
* Osteosarcoma
* Synovial sarcoma
* Rhabdomyosarcoma (e.g., alveolar, embryonal, or pleomorphic)
* Liposarcoma (all variants)
* Malignant fibrous histiocytoma
* Peripheral nerve sheath (e.g., malignant peripheral nerve sheath tumor, neurofibrosarcoma, or schwannoma)
* Fibrosarcoma
* Angiosarcoma (all variants)
* Failed standard therapy with no available salvage regimens
* Unidimensionally measurable target lesions by x-ray, CT scan, MRI, PET, or physical examination
* Must be outside prior irradiation fields or have documented disease progression at least 6 weeks after completion of prior radiotherapy
PATIENT CHARACTERISTICS:
Age:
* 10 and over
Performance status:
* Not specified
Life expectancy:
* Not specified
Hematopoietic:
* Not specified
Hepatic:
* Bilirubin no greater than 3 times upper limit of normal (ULN)
* ALT and AST less than 2.5 times ULN
Renal:
* Creatinine less than 1.5 times ULN
Other:
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective barrier contraception during and for at least 1 week after study participation for female patients and for at least 3 months after study participation for male patients
PRIOR CONCURRENT THER…