Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer (NCT00031785) | Clinical Trial Compass
CompletedPhase 3
Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer
United States25 participantsStarted 2000-09-01
Plain-language summary
RATIONALE: Megestrol helps improve appetite. It is not yet known if megestrol is effective in limiting weight loss in patients who are undergoing radiation therapy.
PURPOSE: Randomized phase III trial to determine the effectiveness of megestrol in limiting weight loss in patients who are undergoing radiation therapy for lung cancer.
Who can participate
Age range18 Years – 120 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed lung cancer
* Unresectable stage I-IIIB non-small cell lung cancer (NSCLC)
* Resected stage I-IIIB NSCLC
* Limited stage small cell lung cancer
* Planned radiotherapy with a total dose of at least 5,000 cGy in fraction sizes of no greater than 200 cGy each
* No distant metastases
* No significant ascites, pleural effusions, or edema that would inhibit oral food intake or invalidate weight determinations
PATIENT CHARACTERISTICS:
Age:
* Over 18
Performance status:
* ECOG 0-2
Life expectancy:
* More than 3 months
Hematopoietic:
* Not specified
Hepatic:
* Not specified
Renal:
* Not specified
Cardiovascular:
* No uncontrolled hypertension
* No active thromboembolic disease
* No myocardial infarction within the past 3 months
* No prior congestive heart failure or thromboembolic events
Pulmonary:
* No prior pulmonary edema
Other:
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* No other malignancy within the past 3 years except curatively treated carcinoma in situ of the cervix or non-melanoma skin cancer
* No uncontrolled diabetes with glycosylated hemoglobin greater than 10%
* No Cushing's syndrome
* No dietary restrictions (e.g., salt, sugar, or lipid)
* No other serious medical or psychiatric illness that would preclude study
PRIOR CONCURRENT THERAPY:
Biologic therapy:
* Not specified
Chemotherapy:
* See Endocrine therapy
Endocrine therapy…