Study of Dehydrex in Patients With Corneal Erosion (NCT00029185) | Clinical Trial Compass
CompletedNot Applicable
Study of Dehydrex in Patients With Corneal Erosion
United States300 participantsStarted 2001-09
Plain-language summary
This is a compassionate-use treatment study to provide Dehydrex to patients with corneal erosion syndrome who have previously used Dehydrex.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria:
* Clinical diagnosis of symptomatic recurrent corneal syndrome due to anterior membrane dystrophy or posttraumatic abrasion
* Not responsive to standard medical therapy with artificial tears, hypertonic saline, or bandage soft contact lenses
* At least 3 episodes of erosion within the past 4 months documented by slit lamp examination
Exclusion criteria:
* Allergy to any component of the medications to be used
* Active ocular surface infection due to bacteria, virus, or fungus
* Chronic atopic disease affecting the ocular surface or adnexa
* Dry eye, exposure, trichiasis, entropion, ectropion, or neurotrophic keratopathy
* Concurrent use of contact lenses
* Diagnosis of persistent epithelial defect in eye to be treated
* Concurrent use of topical medication to eye to be treated
* Any ocular eyelid surgery within the past 6 months
* Pre-existing corneal stromal edema
* Diabetes mellitus
* Postsurgical infection
* Dry eye condition of 16 or greater on Patient's Dry Eye Questionnaire
* Other investigational medications within the past 6 months
* Other corneal dystrophy