Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory… (NCT00019019) | Clinical Trial Compass
CompletedPhase 1
Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas
United States70 participantsStarted 1994-10
Plain-language summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
PURPOSE: This phase I trial is studying the side effects and best dose of carboxyamidotriazole and paclitaxel in treating patients with advanced solid tumors or refractory lymphomas.
Who can participate
Age range18 Years
SexALL
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DISEASE CHARACTERISTICS:
* Histologically diagnosed solid tumor (i.e., breast and ovarian epithelial carcinomas) or lymphoma
* Slides reviewed at the NCI Laboratory of Pathology
* Failure on therapy of proven efficacy for the disease
* Prior therapy not required for the following metastatic diseases:
* Melanoma
* Non-small cell lung cancer
* Renal cell carcinoma
* No brain metastases
* Primary brain tumors (such as glioblastoma multiforme) with stable neurologic deficits allowed
* Measurable or evaluable disease required
* Demonstrated by physical exam or on radiograph within 2 weeks prior to initiation of treatment OR
* Elevated PSA associated with prostate cancer
* Other marker-only disease ineligible
PATIENT CHARACTERISTICS:
Age:
* Over 18
Performance status:
* ECOG 0-2
Life expectancy:
* At least 3 months
Hematopoietic:
* WBC at least 3,000/mm\^3
* Platelet count at least 100,000/mm\^3
* Hematocrit at least 27%
Hepatic:
* Liver function tests no greater than 2 times upper limit of normal
* Bilirubin normal
* PT or PTT no greater than 1.25 times upper limit of normal
* Clotting parameters normal
* No concurrent anticoagulants other than 1 mg of warfarin per day for prophylaxis
Renal:
* Creatinine no greater than 1.5 mg/dL OR
* Creatinine clearance at least 45 mL/min
* No kidney obstruction
Cardiovascular:
* No cardiac conduction defect requiring antiarrhythmics
* No evidence of myocardial infarction or other myocardial damage…
Trial details
NCT IDNCT00019019
SponsorNational Institutes of Health Clinical Center (CC)