Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma (NCT00010049) | Clinical Trial Compass
CompletedPhase 1/2
Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma
United States105 participantsStarted 2001-02-27
Plain-language summary
RATIONALE: Imatinib mesylate may interfere with the growth of tumor cells and may be an effective treatment for recurrent glioma and meningioma.
PURPOSE: Phase I/II trial to study the effectiveness of imatinib mesylate in treating patients who have progressive, recurrent, or unresectable malignant glioma or meningioma.
Who can participate
Age range18 Years – 120 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed recurrent or unresectable malignant glioma
* Glioblastoma multiforme (phase I only)
* Anaplastic astrocytoma
* Anaplastic oligodendroglioma
* Anaplastic mixed oligoastrocytoma
* Malignant astrocytoma not otherwise specified
* Gliosarcoma
* Low-grade histology with subsequent diagnosis of malignant glioma allowed (phase I only) OR
* Histologically confirmed recurrent or unresectable benign or malignant meningioma (phase I only)
* No prior intracranial hemorrhage
* Failed prior radiotherapy
* Progressive or recurrent disease by MRI or CT scan and/or resection
* PET or thallium scan, MR spectroscopy, or surgical documentation required in patients who have received prior interstitial brachytherapy or stereotactic radiosurgery
* Stable dose of steroids for 5-7 days prior to MRI or CT scan
PATIENT CHARACTERISTICS:
Age:
* 18 and over
Performance status:
* Karnofsky 60-100%
Life expectancy:
* More than 8 weeks
Hematopoietic:
* Absolute neutrophil count at least 1,500/mm\^3
* Platelet count at least 100,000/mm\^3
* Hemoglobin at least 10 g/dL (transfusion allowed)
Hepatic:
* Bilirubin less than 2 times upper limit of normal (ULN)
* SGOT less than 2 times ULN
* No significant hepatic disease
Renal:
* Creatinine less than 1.5 mg/dL
* Creatinine clearance at least 60 mL/min
* No significant renal disease
Cardiovascular:
* No significant cardiac disease
* No deep venous or arterial thrombosis within th…
Trial details
NCT IDNCT00010049
SponsorSidney Kimmel Comprehensive Cancer Center at Johns Hopkins