Immunotoxin Therapy in Treating Patients With Advanced Cancer (NCT00006981) | Clinical Trial Compass
CompletedPhase 1
Immunotoxin Therapy in Treating Patients With Advanced Cancer
United StatesStarted 2000-12
Plain-language summary
RATIONALE: Immunotoxins can locate tumor cells and kill them without harming normal cells. Immunotoxin therapy may be an effective treatment for advanced cancer.
PURPOSE: Phase I trial to study the effectiveness of immunotoxins in treating patients who have advanced cancer.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed malignancy, including one of the following:
* Malignant mesothelioma
* Ovarian epithelial carcinoma (mucinous or nonmucinous), including primary peritoneal or fallopian tube carcinoma
* Tumors that may have originated in the bowel (e.g., appendiceal carcinoma) and involve the ovary
* Ovarian cancers of other histology are eligible provided they express mesothelin
* Pancreatic cancer
* Squamous cell lung cancer
* Squamous cell cancer of the head and neck
* Squamous cell cancer of the cervix
* Recurrent unresectable disease after prior standard anticancer therapy that was expected to prolong survival and improve quality of life OR unwilling to receive standard anticancer therapy
* At least 30% of initial or recurrent tumor cells positive (at least 1+) for mesothelin by immunohistochemistry
* Measurable or evaluable disease
* No known CNS or spinal cord involvement
* No clinically significant pericardial effusion
PATIENT CHARACTERISTICS:
Age:
* 18 and over
Performance status:
* ECOG 0-2
Life expectancy:
* At least 12 weeks
Hematopoietic:
* Absolute neutrophil count at least 1,000/mm\^3
* Platelet count at least 75,000/mm\^3
Hepatic:
* Bilirubin no greater than upper limit of normal (ULN)
* AST and ALT no greater than 2.5 times ULN
* Albumin at least 3.0 g/dL
* Hepatitis B and C negative
Renal:
* Creatinine no greater than ULN OR
* Creatinine no greater than 2.0 mg/dL if creatinine clearance a…