Non-Ablative Allo HSCT For Hematologic Malignancies or SAA (NCT00006379) | Clinical Trial Compass
CompletedPhase 2
Non-Ablative Allo HSCT For Hematologic Malignancies or SAA
United States58 participantsStarted 2000-06
Plain-language summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill cancer cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by peripheral stem cell transplantation in treating patients who have hematologic cancer or aplastic anemia.
Who can participate
Age range70 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically proven high-risk hematologic malignancy
* Acute non-lymphocytic leukemia (ANLL) after induction failure, or in first complete remission (CR) with high-risk features, including any of the following:
* Stem cell or biphenotypic classification (AML-M0)
* Erythroleukemia (AML-M6)
* Acute megakaryocytic leukemia (AML-M7)
* Cytogenetic markers indicative of poor prognosis
* Failure to achieve CR after standard induction therapy
* Acute lymphocytic leukemia (ALL) or ANLL in relapse or second or subsequent remission
* Chronic myelogenous leukemia (CML) in chronic or accelerated phase
* Patients with CML in blast crisis are eligible after reinduction chemotherapy places them in chronic phase
* High-risk ALL in first CR with high risk defined by presence of t(4;11), t(9;22) translocation, hyperleukocytosis (initial WBC greater than 30,000/mm\^3), or failure to achieve CR by day 28 after standard induction
* No T-cell ALL or t(8;14) positive B-cell ALL in first remission with hyperleukocytosis
* Myelodysplastic syndrome by peripheral blood smear and bone marrow examination
* Refractory to medical management OR
* Cytogenetic abnormalities predictive of transformation into acute leukemia including 5q-, 7q-, monosomy 7, and trisomy 8 OR
* Evidence of evolution to AML (e.g., refractory anemia with excess blasts (RAEB) or RAEB in transformation)
* Multiple myeloma, non-Hodgkin's lymphoma (NHL)ā¦