Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study

* INCLUSION AND EXCLUSION CRITERIA: Inclusion and exclusion criteria for each group are outlined below. The total accrual ceiling is 2050, including subjects of both sexes, made up of the following 11 populations: Pediatric patients with bipolar disorder or SMIBRD: INCLUSION CRITERIA: * Age 6-17 * Meet DSM criteria for BD * Have a primary caregiver who can accompany him or her on trips to NIMH and provide reliable history and information. * Have a psychiatrist who provides clinical care for their BSD. * Be able to complete self-rating forms and to cooperate with other study procedures. EXCLUSION CRITERIA: * I.Q. \< 70 * Autistic disorder or more than mild autism spectrum disorder; * Psychosis that interferes with the child s capacity to understand and comply with study procedures * Unstable medical illness (e.g. severe asthma) * Medical illness that could cause the symptoms of BSD (e.g. multiple sclerosis, thyroid disease) * Pregnancy * Substance abuse within two months of the initial evaluation, since alcohol and abused substances interfere with interpretation of fMRI and cognitive task data. * NIMH IRP Employee family member Adults with BD participating as individuals or as parents of at- risk children: INCLUSION CRITERIA: * DSM Bipolar Disorder * Age 18-58 * Be able to complete self-rating forms and to cooperate with other study procedures. * Medically safe to perform MRI EXCLUSION CRITERIA: * Diagnosis of schizophrenia or other current psychosis. * Claustrophob…