Treating Patients With Advanced Solid Tumors, Breast Cancer or Recurrent Ovarian Cancer

Inclusion Criteria: * Histologically or cytologically confirmed metastatic or unresectable solid malignancy for which no standard or curative therapies exist or are no longer effective * Metastatic, recurrent, or locally advanced breast, ovarian, or other cancer * Hemoglobin at least 9.0 g/dL * WBC at least 3,000/mm3 * Absolute neutrophil count at least 1,500/mm3 * Platelet count at least 100,000/mm3 * Bilirubin normal * AST/ALT no greater than 3 times upper limit of normal * Gilbert's syndrome allowed * Creatinine no greater than 2 mg/dL Exclusion Criteria: * symptomatic congestive heart failure * unstable angina pectoris * cardiac arrhythmia * grade 2 or greater clinical neuropathy * prior allergy or hypersensitivity reaction (grade 2 or greater) to prior paclitaxel or other therapy containing Cremophor EL * allergy or intolerance to steroids, diphenhydramine, cimetidine, or ranitidine * uncontrolled concurrent illness * active infection * pregnant or nursing * other concurrent anticancer therapies or commercial agents * other concurrent investigational agents * other concurrent highly active antiretroviral therapy for HIV-positive patients