Bone Marrow Transplant in Treating Patients With Hematologic Cancers (NCT00005797) | Clinical Trial Compass
CompletedPhase 2
Bone Marrow Transplant in Treating Patients With Hematologic Cancers
United States125 participantsStarted 1993-03
Plain-language summary
RATIONALE: Giving chemotherapy drugs and total-body irradiation before a donor bone marrow transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets.
PURPOSE: This phase II trial is studying how well donor bone marrow transplant works in treating patients with hematologic cancers.
Who can participate
Age range15 Years – 55 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed diagnosis of:
* Acute myelogenous leukemia
* Complete remission (CR) 1 - ALL except good cytogenetics defined as \[(inv16, t(8,21), t(15,17)\]
* CR2
* Induction failures
* Relapsed OR
* Acute lymphocytic leukemia (ALL)
* CR1 - high risk defined as overt CNS involvement, 1 or more risk factors (age 30 and over, WBC at least 20,000/mm\^3, at least 4 weeks to CR1, myeloid phenotype)
* CR2
* Induction failures
* Relapsed OR
* Chronic myelogenous leukemia
* Chronic phase (CP) 1
* Accelerated phase (AP)/CP2 OR
* Chronic lymphocytic leukemia
* At diagnosis - RAI stage III/IV or Binet C
* Must undergo 1 induction regimen
* Relapsed - any stage
* Must have received no more than 3 regimens for diagnosis OR
* Multiple myeloma
* At diagnosis - stage II/III (primary refractory or sensitive)
* Relapsed no more than 2 times - sensitive disease
* Plasma cell leukemia OR
* Myelodysplasia
* All subtypes eligible OR
* Myeloproliferative disorders
* Poor response to medical therapy OR
* Cytogenetic abnormalities
* Must have a related donor who is genotypic 6 out of 6 HLA A, B, and DR match
* Molecular DR matching required
PATIENT CHARACTERISTICS:
Age:
* 15 to 55
Performance status:
* Karnofsky 80-100%
Life expectancy:
* Not specified
Hematopoietic:
* See Disease Characteristics
Hepatic:
* Bilirubin no greater than 2.0 mg/dL…
What they're measuring
1
Relapse-free survival
Timeframe: 5 years post transplant
Trial details
NCT IDNCT00005797
SponsorH. Lee Moffitt Cancer Center and Research Institute