Donor Bone Marrow Transplant in Treating Patients With Leukemia, Lymphoma, or Nonmalignant Hemato… (NCT00005622) | Clinical Trial Compass
CompletedPhase 2
Donor Bone Marrow Transplant in Treating Patients With Leukemia, Lymphoma, or Nonmalignant Hematologic Disorders
United States72 participantsStarted 1996-05
Plain-language summary
RATIONALE: Giving chemotherapy and total-body irradiation before a donor bone marrow transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. When the stem cells from a related or unrelated donor, that closely matches the patient's blood, are infused into the patient they may help the patient's bone marrow to make stem cells, red blood cells, white blood cells, and platelets.
PURPOSE: This phase II trial is studying how well donor bone marrow transplant works in treating patients with leukemia, lymphoma, or nonmalignant hematologic disorders.
Who can participate
Age range15 Years – 50 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed diagnosis of one of the following:
* Acute lymphocytic leukemia (ALL):
* Complete remission (CR) 1 - high risk defined as overt CNS involvement or poor cytogenetics (additions, deletions, translocations, or multiple abnormalities)
* CR2
* Induction failures
* Relapse - patients with at least 10% marrow blasts undergo at least one reinduction attempt
* Acute myelogenous leukemia (AML):
* CR1 - high risk defined as poor cytogenetics (deletions, additions, multiple abnormalities)
* CR2
* Induction failures
* Relapse - patients with at least 10% marrow blasts undergo at least one reinduction attempt
* Chronic myelogenous leukemia (CML):
* Chronic phase (CP) 1
* Accelerated phase/CP2 - patients in blast phase must undergo treatment and achieve a second chronic phase prior to transplant
* Chronic lymphocytic leukemia (CLL):
* Relapse - any stage; must have received no more than 3 prior regimens
* Multiple myeloma:
* At diagnosis - primary refractory
* Relapse (no more than 2) - sensitive disease
* Plasma cell leukemia
* Inability to achieve a complete remission after autologous transplant (no older than 40)
* Myelodysplasia - all subtypes
* Myeloproliferative disorders - patients with poor response to medical therapy or cytogenetic abnormalities
* Severe aplastic anemia (SAA):
* Very SAA - at diagnosis
* SAA - induction therapy
* Donors mus…
What they're measuring
1
event free survival (EFS)
Timeframe: five year post transplant
Trial details
NCT IDNCT00005622
SponsorH. Lee Moffitt Cancer Center and Research Institute