DX-8951f in Treating Children With Advanced Solid Tumors or Lymphomas (NCT00004212) | Clinical Trial Compass
CompletedPhase 1
DX-8951f in Treating Children With Advanced Solid Tumors or Lymphomas
United StatesStarted 1999-09
Plain-language summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
PURPOSE: Phase I trial to study the effectiveness of DX-8951f in treating children who have advanced solid tumors or lymphomas that have not responded to previous therapy.
Who can participate
Age range21 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed advanced solid tumors, including brain tumors and lymphomas, that have failed standard therapy (surgery, radiotherapy, endocrine therapy, or chemotherapy) or for which no standard therapy exists
* Histology requirement waived for brain stem gliomas
PATIENT CHARACTERISTICS:
Age:
* 21 and under at diagnosis
Performance status:
* ECOG 0-2
Life expectancy:
* At least 8 weeks
Hematopoietic:
* Absolute neutrophil count at least 750/mm\^3
* Platelet count at least 75,000/mm\^3
* Hemoglobin at least 8.5 g/dL
Hepatic:
* Bilirubin no greater than 1.5 mg/dL
* SGOT or SGPT no greater than 2.5 times upper limit of normal (ULN) (5 times ULN if liver metastases)
Renal:
* Creatinine no greater than 1.5 times ULN OR
* GFR at least 70 mL/min
Other:
* Not pregnant or nursing
* Negative pregnancy test
* No history of severe or life-threatening hypersensitivity to camptothecin analogs
* HIV negative
* No other concurrent severe or uncontrolled medical illness
* No systemic infection
PRIOR CONCURRENT THERAPY:
Biologic therapy:
* Recovered from prior immunotherapy
Chemotherapy:
* See Disease Characteristics
* Recovered from prior chemotherapy
Endocrine therapy:
* See Disease Characteristics
Radiotherapy:
* See Disease Characteristics
* At least 4 weeks since prior extensive radiotherapy involving cranial, whole pelvic, or at least 25% of bone marrow reserve
* Recovered from prior radiotherapy
* Concurrent localized radi…