Colony-Stimulating Factors to Relieve Neutropenia in Patients With Recurrent Non-Hodgkin's Lymphoma

Inclusion Criteria: * Diagnosis of non-Hodgkin's lymphoma (NHL) o Relapsed disease or Refractory to first line cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy * Age 18 and over * ECOG 0-2Absolute neutrophil count at least 1,500/mm3Platelet count at least 150,000/mm3 * Creatinine not greater than 1.5 mg/dL or Creatinine clearance greater than 60 mL/min * Fertile patients must use effective barrier contraception * At least 4 weeks since prior radiotherapy * At least 72 hours since prior antimicrobials * At least 30 days since other prior investigational drug Exclusion Criteria: * No myelodysplastic syndrome or chronic myeloid leukemia * Not pregnant or nursing/Negative pregnancy test * No other prior malignancy except * Curatively treated basal cell or squamous cell carcinoma * Carcinoma in situ of the cervix * Surgically cured malignancy * No hypersensitivity to E. coli derived products (e.g., filgrastim (G-CSF), insulin, asparaginase) * No prior bone marrow or peripheral blood stem cell (PBSC) transplantation for NHL * No prior filgrastim-SD/01 * No other concurrent myelopoietic growth factors * No concurrent WBC transfusions * No concurrent PBSC collection * No more than 2 prior courses of chemotherapy for any malignancy * No concurrent corticosteroids except topical steroids or as pre-medications or associated with chemotherapy * No other concurrent investigational drug * No concurrent prophylactic antibiotics during course 1