Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, … (NCT00003308) | Clinical Trial Compass
CompletedPhase 2
Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma
United StatesStarted 1999-02-02
Plain-language summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells.
PURPOSE: Phase II trial to study the effectiveness of radiation therapy in treating patients with newly diagnosed brain metastases from kidney cancer, melanoma, or sarcoma.
Who can participate
Age range18 Years – 120 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed renal cell carcinoma, melanoma, or sarcoma with 1-3 newly diagnosed intraparenchymal brain metastases based on contrast-enhanced MRI (CT scan acceptable if patients have a medical contraindication to MRI)
* No lesion greater than 4.0 cm in diameter and, if multiple lesions are present, no more than one greater than 3.0 cm in diameter
* No limitation on the extent of extracranial metastatic disease
* No metastases in the brain stem, midbrain, pons, or medulla
* No leptomeningeal metastases documented by MRI or CSF evaluation
* No metastases within 10 mm of optic nerve or chiasm
* No history of multiple liver metastases
PATIENT CHARACTERISTICS:
Age:
* 18 and over
Performance status:
* ECOG 0-2
Life expectancy:
* At least 3 months
Hematopoietic:
* Absolute neutrophil count greater than 1,000/mm\^3
* Platelet count greater than 50,000/mm\^3
* Hemoglobin greater than 8 g/dL
Hepatic:
* Not specified
Renal:
* Not specified
Other:
* No major medical illness
* No psychoses
* Not pregnant or nursing
* Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy:
* Not specified
Chemotherapy:
* Prior chemotherapy allowed
* Systemic chemotherapy may be continued at the discretion of investigator after completion of radiosurgery
Endocrine therapy:
* Not specified
Radiotherapy:
* No prior cranial radiotherapy
* Prior or concurrent radiotherapy to noncranial sites allowed
Surgery:
…