Paclitaxel in Treating Patients With AIDS-Related Kaposi's Sarcoma (NCT00003008) | Clinical Trial Compass
CompletedPhase 2
Paclitaxel in Treating Patients With AIDS-Related Kaposi's Sarcoma
United States33 participantsStarted 1997-12-15
Plain-language summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of paclitaxel in treating patients with AIDS-related Kaposi's sarcoma.
Who can participate
Age range18 Years – 120 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed Kaposi's sarcoma requiring chemotherapy and/or currently being treated with paclitaxel
* Serologic diagnosis of HIV infection documented by a positive ELISA and confirmed with a Western Blot or other federally approved HIV diagnostic test
PATIENT CHARACTERISTICS:
Age:
* 18 and over
Performance status:
* ECOG 0-2
Life expectancy:
* Not specified
Hematopoietic:
* Absolute neutrophil count at least 1,000/mm \^3(with or without the use of colony-stimulating factors)
* Platelet count at least 50,000/mm\^3
Hepatic:
* Bilirubin no greater than 1.5 times upper limit of normal (ULN)
* AST no greater than 2.5 times ULN
* Alkaline phosphatase no greater than 2.5 times ULN
Renal:
* Creatinine no greater than 1.5 mg/dL OR
* Creatinine clearance greater than 60 mL/min
Neurologic:
* No greater than grade 2 peripheral neuropathy
* No neuropsychiatric history or altered mental status that would preclude study
Other:
* Not pregnant or nursing
* Fertile patients must use effective contraception
* No other prior or concurrent malignancy except curatively treated carcinoma in situ of the cervix or basal cell or squamous cell skin cancer
* No sensitivity to E. coli-derived proteins
* No active untreated infection
* No new infectious complications requiring a change in antibiotics within the past 2 weeks
PRIOR CONCURRENT THERAPY:
Biologic therapy:
* Not specified
Chemotherapy:
* See Disease Characteristics
Endocrine therapy…