Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Mening… (NCT00002965) | Clinical Trial Compass
CompletedPhase 2
Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas
United States16 participantsStarted 1997-01
Plain-language summary
RATIONALE: Interferon alfa may interfere with the growth of cancer cells.
PURPOSE: Phase II trial to study the effectiveness of interferon alfa in treating patients with recurrent unresectable meningiomas and malignant meningiomas.
Who can participate
Age range16 Years
SexALL
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DISEASE CHARACTERISTICS:
* Histologically proven tumors:
* Unresectable meningioma
* Atypical meningioma
* Malignant meningioma
* Angioblastic meningioma
* Hemangiopericytoma
* Recurrent or progressive, unresectable tumor after failing radiation therapy or refused radiation therapy following 2 surgeries
PATIENT CHARACTERISTICS:
Age:
* 16 and over
Performance status:
* Karnofsky at least 60%
Life expectancy:
* At least 3 months
Hematopoietic:
* AGC at least 1,500/mm\^3
* Platelet count at least 100,000/mm\^3
Hepatic:
* SGPT less than 2.0 times normal
* Alkaline phosphatase less than 2.0 times normal
* Bilirubin less than 1.5 mg/dL
Renal:
* BUN less than 1.5 times normal OR
* Creatinine less than 1.5 times normal
Other:
* No active infection
* No diseases that obscure toxicity or dangerously alter drug metabolism
* No serious intercurrent medical illness
* Not pregnant
* Fertile patients must use adequate contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy:
* No concurrent biologic therapy
Chemotherapy:
* Prior chemotherapy allowed and recovered from all myelotoxicity secondary to the therapy
Endocrine therapy:
* Prior hormonal therapy allowed
* No concurrent hormonal therapy
Radiotherapy:
* Prior radiotherapy allowed
Surgery:
* Not specified
What they're measuring
1
Number of Patients with Dose Limiting Toxicity (DLT)