The Safety and Effectiveness of SPC3 in HIV-1 Infected Patients

Inclusion Criteria Concurrent Medication: Allowed: * Antiretrovirals provided regimen has been stable for at least 6 weeks prior to study screening. Patients must have: * HIV seropositivity for at least 6 months. * CD4 \>= 100 cells/mm3. * HIV RNA PCR (Amplicor) \> 10,000 copies/ml. * No significant active opportunistic infection or tumor at study entry. FDA DISCLAIMER: * The FDA encourages the inclusion of females of childbearing potential in study protocols, but the sponsor of this protocol specifically excludes females of childbearing potential from this study and includes only females who are sterile. Any questions about these inclusion/exclusion criteria should be directed to the study's contact person. Prior Medication: Allowed: * Prior antiretrovirals. Exclusion Criteria Co-existing Condition: Patients with the following conditions are excluded: Inability to communicate with investigator or deemed likely to be noncompliant on study. Concurrent Medication: Excluded: * Any drug that may interact with SPC3 (e.g., suramin). Patients with the following prior condition are excluded: History of relevant drug hypersensitivity. Prior Medication: Excluded: * Investigational drug within the past 4 weeks.