ARNI

Clinical trial pipeline · Data from ClinicalTrials.gov

See which ARNI trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

RecruitingPhase 2

NCT06655480

Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF

Patients with advanced heart failure with preserved ejection fraction (HFpEF) will be randomly assigned in open-label multicenter study to receive triple combin…

Russia50 participantsStarted 2025-03-18

Treatment: [ARNI + SGLTi + AMR], [SGLTi + previously taken RAAS blocker]

RecruitingNot Applicable

NCT07347925

Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF

This study looks at people with heart failure who are admitted to the hospital. The goal of the study is to understand whether taking a heart failure medicine c…

Egypt140 participantsStarted 2026-01-10

Treatment: Prehospital ARNI use, No prehospital ARNI use

RecruitingPhase 4

NCT04191681

Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study

The purpose of the study is to evaluate how well tolerated and effective an angiotensin receptor-neprilysin inhibitor (sacubitril-valsartan) is in patients with…

United States50 participantsStarted 2019-11-08

Treatment: Sacubitril-Valsartan, Usual care (standard-of-care) arm

All recent trials (38 shown)

Not Yet RecruitingPhase 4

NCT07572032

Delayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected Aetiology (DELAY-HF), Pilot Study

In patients with heart failure due to a reversible underlying cause-such as valvular heart disease or coronary artery disease-surgical or procedural correction…

South Korea80 participantsStarted 2026-05-20

Treatment: Sacubitril / Valsartan, SGLT-2 inhibitor

CompletedNot Applicable

NCT07379788

ARNI Combined With SGLT2 Inhibitors on Functional Mitral Regurgitation Remodeling

This study aimed to compare the effects of ARNI monotherapy versus combined ARNI and SGLT2 inhibitor therapy on Mitral Remodeling Index (MRIx) and Functional mi…

Saudi Arabia180 participantsStarted 2025-12-25

Treatment: Sacubitril/Valsartan 49 MG-51 MG Oral Tablet [ENTRESTO], Empagliflozin10Mg Tab

ARNI

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF

Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF

Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study

All recent trials (38 shown)

Delayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected Aetiology (DELAY-HF), Pilot Study

ARNI Combined With SGLT2 Inhibitors on Functional Mitral Regurgitation Remodeling

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF

Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF

Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study

All recent trials (38 shown)

Delayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected Aetiology (DELAY-HF), Pilot Study

ARNI Combined With SGLT2 Inhibitors on Functional Mitral Regurgitation Remodeling

Hemodynamic Effects of ARNI on Noninvasive Pressure-volume Analysis in Patients With Chronic Heart Failure

A Real-world Study of the Effectiveness of Angiotensin Receptor-Neprilysin Inhibitor Therapy in Hypertensive Patients in…

PDD in Type 2 Diabetes w/wo Diastolic Dysfunction

The Efficacy and Safety of ARNI on the Outcome of Advanced Lung Cancer With Concurrent Hypertension

Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Pat…

Initiation of ARNi and SGLT2i in Patients With HFrEF

Comparative Efficacy of ARNI Versus ACE Inhibitor Therapy in Egyptian Children With Dilated Cardiomyopathy

Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Hea…

Role of ARNi in Ventricular Remodeling in Hypertensive LVH

Effective Study of ARNI on Ventricular Arrhythmia in HFrEF Patients With ICD or CRT-D (RHYTHM)

Protecting With ARNI Against Cardiac Consequences of Coronavirus Disease 2019

ARNI Versus plAcebo in Patients With Congenital sYStemic Right Ventricle Heart Failure

COmparing arNi and Ace For Improving Erectile Dysfunction in mEN With reduCed Ejection Fraction Heart Failure

The Comparative Effectiveness Between ARNI and ACE Inhibitor/ARB Medication in Patient With HFrEF

Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI

Sacubitril/Valsartan Versus Amlodipine in Hypertension and Left Ventricular Hypertrophy.

Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy

Lifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy